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Problems with B12 deficiency A lack of B12 in your body affects several nervous system and red blood cell functions, which can lead to things like: Anemia: causes fewer red blood cells to move from your bone marrow Birth problems: increases risk of pregnancy loss and neural tube defects Osteoporosis: leads to poor bone health and fracture risk Macular degeneration: progression of age-related macular degeneration Memory loss: the onset of early-stage dementia is greater The advantages of B12 injections The decision to get a B12 shot instead of a supplement depends on factors such as your level of vitamin deficiency, the presence of symptoms, and how your need changes over time